Roxatidine Impurity 50 CAS 78274-00-7 (free base)
| CAS No. | 78274-00-7 (free base) |
| Molecular Formula | C16H24N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roxatidine Impurity 50.
CATO supplies Roxatidine Impurity 50 (CAS 78274-00-7 (free base)), a pharmacopoeial impurity reference standard (molecular formula C16H24N2O2HCl, MW 312.84 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Roxatidine Impurity 50 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 312.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Roxatidine Impurity 50 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H24N2O2 HCl |
| Molecular Weight | 312.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Roxatidine Standards
- Roxatidine Impurity 43 (CAS 100-83-4)
- Roxatidine Impurity 55 (CAS 100841-00-7)
- Roxatidine Impurity 21 (CAS 108441-34-5)
- Roxatidine Hemioxalate (CAS 110925-92-3)
- Roxatidine Impurity 58 (CAS 115062-97-0)
- Roxatidine Impurity 56 (CAS 132513-51-0)
- Roxatidine Impurity 34 (CAS 15504-60-6)
- Roxatidine Impurity 3 (CAS 195621-06-8)
Recommended Standards
- Cefmetazole Impurity 1 (CAS 56796-16-8)
- Ampicillin Impurity 31 (CAS CATO-C4X-144331)
- Oxaliplatin EP Impurity E (CAS 82398-34-3)
- 6-Fluoro-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-10-one (CAS 1338665-61-4)
- LysoPE(18:2/0:0) (CAS 85046-18-0)
- 2-Cyclopropoxy-5-(dimethylamino)-N,N-dimethylbenzamide (CAS 1243374-00-6)
- 2-Amino-7H-purine-6-carbonitrile (CAS 37635-77-1)
- Benidipine Impurity 59 (CAS 61311-83-9)
- 1-Methyl-1,5-diazecane dihydrochloride (CAS 2137780-61-9)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com